Vitamin B12 injection
A pink to red transparent liquid.
Hydroxocobalamin is a man-made injectable form of vitamin B12 used to treat low levels (deficiency) of this vitamin. Vitamin B12 helps your body use fat and carbohydrates for energy and make new protein. It is also important for normal blood, cells, and nerves. Most people get enough vitamin B12 in their diet, but a deficiency may occur in certain health conditions (e.g., poor nutrition, stomach/intestinal problems, infection, cancer). Serious vitamin B12 deficiency may result in anemia, stomach problems, and nerve damage.
Dosage and Administration
The following dosage schemes are suitable for adults and children.
Addisonian pernicious anaemias and other macrocytic anaemias without neurological involvement.
Initially 250 to 1000 micrograms intramuscularly on alternate days for one or two weeks, then 250 micrograms weekly until the blood count is normal
Maintenance: 1000 micrograms every two to three months
Addisonian pernicious anaemia and other macrocytic anaemias with neurological involvement
Initially:1000 micrograms on alternate days as long as improvement is occurring.
Maintenance:1000 micrograms every two of three months.
Prophylaxis of macrocytic anaemia associated with vitamin B12 deficiency resulting from gastrectomy, some malabsorption syndromes and strict vegetarianism
1000 micrograms every two or three months.
Tobacco amblyopia and Leber's optic atrophy
Initially:1000 micrograms daily by intramuscular injection for two weeks then twice weekly as long as improvement is occurring.
Maintenance: 1000 micrograms every one to three months as required.
Pain at the injection site, mild diarrhea, itching, or a feeling of swelling all over the body may occur.
If any of these effects persist or worsen,tell your doctor or pharmacist promptly.This medication may cause low potassium levels in the blood (hypokalemia). Tell your doctor immediately if any of these unlikely but serious side effects occur: muscle cramps, weakness, irregular heartbeat.People who have a rare blood disorder (polycythemia vera) may infrequently have symptoms related to this disorder while taking hydroxocobalamin. Get medical help right away if any of these rare but very serious symptoms occur: chest pain (especially with shortness of breath), weakness on one side of the body, sudden vision changes, slurred speech.
Hypersensitivity to Hydroxocobalamin or to any of the ingredient in this preparation.
Vitamin B12 is extensively bound to specific plasma proteins called transcobalamins; transcobalamin II appears to be involved in the rapid transport of the cobalamins to tissues. It is stored in the liver, excreted in the bile, and undergoes enterohepatic recycling; part of a dose is excreted in the urine, most of it in the first 8 hours..
Before using hydroxocobalamin, tell your doctor or pharmacist if you are allergic to it; or to cobalt; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: low potassium blood levels (hypokalemia), gout, a certain blood disorder (polycythemia vera), a certain eye disease (Leber's disease), other vitamin/mineral deficiencies (especially folic acid and iron).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.Based on information from related drugs, this medication may pass into breast milk. Consult your doctor before breast-feeding