Magnesium sulfate injection
A colorless transparent liquid.
Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) is indicated in the following conditions:
Convulsions (treatment) - Intravenous magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) is indicated for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children.
Hypomagnesemia (prophylaxis and treatment) - Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) is indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia.
Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) is also used to prevent or treat magnesium deficiency in patients receiving total parenteral nutrition.
Tetany, uterine (treatment) - Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) is indicated in uterine tetany as a myometrial relaxant.
Flushing, sweating, sharply lowered blood pressure, hypothermia, stupor and ultimately, respiratory depression..
Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) should not be administered parenterally in patients with heart block or myocardial damage.
When barbiturates, narcotics, or other hypnotics (or systemic anesthetics) are to be given in conjunction with magnesium, their dosage should be adjusted with caution because of the additive central depressive effects of magnesium.
Pregnancy - Teratogenic effects: Pregnancy category C. Animal reproduction studies have not been conducted with Magnesium Sulfate Injection, USP 50%. It is also not known whether Magnesium Sulfate Injection, USP 50% can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Magnesium Sulfate Injection, USP 50% should be given to a pregnant woman only if clearly needed.
Magnesium is the second most plentiful cation of the intracellular fluids. It is essential for the activity of many enzyme systems and plays an important role with regard to neurochemical transmission and muscular excitability. Deficits are accompanied by a variety of structural and functional disturbances.
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