Calcium Carbonate Tablets

Calcium carbonate is a dietary supplement used when the amount of calcium taken in the diet is not enough. Calcium is needed by the body for healthy bones, muscles, nervous system, and heart.

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Calcium carbonate tablets

Calcium carbonate tablets 500

Product Name:Calcium carbonate tablet

Nombre del Producto: Tabletas de carbonato de calcio

Specification: 500mg,1g

Package: 100tablets/bottle

Standard: USP


Calcium carbonate also is used as an antacid to relieve heartburn, acid indigestion, and upset stomach. It is available with or without a prescription. 

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

 

Dosage Forms

Oral:

Calcium: 1250 mg (elemental calcium 500 mg) [DSC]

 

Pharmacologic Category

Antacid

Antidote

Calcium Salt

Electrolyte Supplement, Oral

Phosphate Binder

Pharmacology

 

As dietary supplement, used to prevent or treat negative calcium balance; in osteoporosis, it helps to prevent or decrease the rate of bone loss. Calcium is an integral component of the skeleton and also moderates nerve and muscle performance and allows normal cardiac function. Also used to treat hyperphosphatemia in patients with chronic kidney disease by combining with dietary phosphate to form insoluble calcium phosphate, which is excreted in feces. Calcium salts as antacids neutralize gastric acidity resulting in increased gastric and duodenal bulb pH; they additionally inhibit proteolytic activity of pepsin if the pH is increased >4 and increase lower esophageal sphincter tone (IOM, 2011).

 

Absorption

Minimal unless chronic, high doses; absorption predominantly in the duodenum and dependent on calcitriol and vitamin D; mean absorption of calcium intake varies with age (infants 60%, prepubertal children 28%, pubertal children 34%, adults 25%); during pregnancy, calcium absorption doubles; calcium is absorbed in soluble, ionized form; solubility of calcium is increased in an acid environment (IOM 2011); decreased absorption occurs in patients with achlorhydria, renal osteodystrophy, steatorrhea, or uremia

 

Distribution

Primarily in bones, teeth (IOM, 2011)

 

Excretion

Primarily feces (75%; as unabsorbed calcium); urine (22%) (IOM, 2011)

 

Protein Binding

~40%, primarily to albumin (Wills 1971)

 

Use: Labeled Indications

Antacid: For the relief of acid indigestion, heartburn, sour stomach, and GI upset associated with these symptoms

Calcium supplementation: For use as a dietary supplement when calcium intake may be inadequate (eg, osteoporosis, osteomalacia, hypocalcemic rickets) (IOM, 2011)

 

Use: Unlabeled

Hyperphosphatemia in chronic kidney disease

 

Contraindications

Hypersensitivity to any component of the formulation

 

Dosage

Oral (dosage is in terms of calcium carbonate, except where noted; calcium carbonate generally provides approximately 40% elemental calcium):

Dietary Reference Intake for Calcium:

0 to <6 months: Adequate intake: 200 mg elemental calcium daily

6 to 12 months: Adequate intake: 260 mg elemental calcium daily

1 to 3 years: RDA: 700 mg elemental calcium daily

4 to 8 years: RDA: 1,000 mg elemental calcium daily

9 to 18 years: RDA: 1,300 mg elemental calcium daily

Adults, Females/Males: RDA:

19 to 50 years: 1,000 mg elemental calcium daily

≥51 years, females: 1,200 mg elemental calcium daily

51 to 70 years, males: 1,000 mg elemental calcium daily

>70 years, males: 1,200 mg elemental calcium daily

 

Females: Pregnancy/Lactating: RDA: Requirements are the same as in nonpregnant or nonlactating females (IOM 2011).

Antacid:

 

Children 2 to 5 years (10.9 to 21.3 kg): 375 to 400 mg as symptoms occur; maximum: 1,500 mg daily for up to 2 weeks; OTC dosing recommendations may vary by product and/or manufacturer; specific product labeling should be consulted.

Children 6 to 11 years (≥21.8 kg): 750 to 800 mg as symptoms occur; maximum: 3,000 mg daily for up to 2 weeks; OTC dosing recommendations may vary by product and/or manufacturer; specific product labeling should be consulted.

Children ≥12 years and Adolescents: 500 to 3,000 mg as symptoms occur for up to 2 weeks; maximum daily dose: 7,500 mg/day; OTC dosing recommendations may vary by product and/or manufacturer; specific product labeling should be consulted.

Adults: Generally, 1 to 4 tablets as symptoms occur; maximum: 8,000 mg daily for up to 2 weeks; OTC dosing recommendations may vary by product and/or manufacturer; specific product labeling should be consulted.

Calcium supplementation:

Children 2 to 4 years: 750 mg twice daily

Children ≥4 years and Adolescents: 750 mg 3 times daily

Adults: 500 mg to 4 g daily in 1 to 3 divided doses; OTC dosing recommendations may vary by product and/or manufacturer; specific product labeling should be consulted.

Hyperphosphatemia in chronic kidney disease (off-label use): Adults: Total dose of elemental calcium (including dietary sources and calcium-based phosphate binders) should not exceed 2,000 mg daily (Eknoyan 2003).

Dosing adjustment in renal impairment: CrCl <25 mL/minute: Dosage adjustments may be necessary depending on the serum calcium levels

Dosing adjustment in hepatic impairment: There are no dosage adjustments provided in the manufacturer's labeling (has not been studied).

 

Administration

 

Oral: Administer with food.

Capsules may be swallowed whole or opened and the contents mixed with food or drink.

Dietary Considerations

Take with food. Limit intake of bran, foods high in oxalates, or whole grain cereals which may decrease calcium absorption.

Some products may contain phenylalanine and/or sodium.

 

Storage

Store between 15°C to 30°C (59°F to 86°F). Protect oral suspension from freezing.


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