Analgesic, antipyretic and anti-inflammatory drugs are a class of antipyretic and analgesic, and most of them have anti-inflammatory and anti-rheumatic effects. Although the chemical structure is different, it can inhibit the biosynthesis of prostaglandins (PG) in the body. Because of its special anti-inflammatory effect, this class of drugs is also called non-steroidal anti-inflammatory drugs (NSAID).
There are many types of analgesic, antipyretic and anti-inflammatory drugs, including salicylic acid, aniline, anthraquinone, aryl acetic acid, aryl propionic acid, enolic acid, pyrazolone, alkanone, etc. . Although these drugs have different structures, they all have similar pharmacological actions, mechanisms of action, and adverse reactions. The main mechanism of action of analgesic, antipyretic and anti-inflammatory drugs is to inhibit the activity of cyclooxygenase (COX) in the body and reduce the biosynthesis of local tissue prostaglandins (PG). According to their selectivity for COX action, they can be classified into non-selective COX inhibitors and selective COX-2 inhibitors.
1. Antipyretic and analgesic and anti-rheumatic effects
(1) Antipyretic and analgesic effects are obviously reliable, and can be used for cold, fever, headache, toothache, neuralgia, joint pain, muscle pain and the like.
(2) strong anti-rheumatic effect. Large dose treatment of acute rheumatoid arthritis, and the effect is rapid and indeed, which can also be used as a differential diagnosis.
2. Inhibit platelet aggregation and prevent thrombosis. Small doses can be used to prevent cerebral thrombosis and myocardial infarction.
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