Multiple Electrolytes Injection 500ml

Multiple Electrolytes Injection 500ml

It is a sterile, nonpyrogenic isotonic solution in a single dose container for intravenous administration. Multiple Electrolytes Injection administered intravenously has value as a source of water, electrolytes, and calories

Details

Multiple Electrolytes Injection 500ml

Product Name : Multiple electrolytes injection

Nombre del Producto : Polielectrolito inyección

Specification: 500ml

Package: Plastic bag,glass bottle

Standard: Internal method


Clinical Pharmacology:

Multiple Electrolytes Injection has value as a source of water and electrolytes. It is capable of inducing diuresis depending on the clinical condition of the patient. Multiple Electrolytes Injection produces a metabolic alkalinizing effect. Acetate and gluconate ions are metabolized ultimately to carbon dioxide and water, which requires the consumption of hydrogen cations.

 

Indications and Usage: 

Multiple Electrolytes Injection is indicated as a source of water and electrolytes or as an alkalinizing agent. Multiple Electrolytes Injection is compatible with blood or blood components. It may be administered prior to or following the infusion of blood through the same administration set (i.e., as a priming solution), added to or infused concurrently with blood components, or used as a diluent in the transfusion of packed erythrocytes. Multiple Electrolytes Injection and 0.9% Sodium Chloride Injection, USP are equally compatible with blood or blood components.

 

Contraindications 

Multiple Electrolytes Injection is contraindicated in patients with a known hypersensitivity to the product.

 

Precautions: 

Do not use plastic containers in series connections. Such use could result in air embolism due to residual air being drawn from the primary container before administration of the fluid from the secondary container is completed. Pressurizing intravenous solutions contained in flexible plastic containers to increase flow rates can result in air embolism if the residual air in the container is not fully evacuated prior to administration. Use of a vented intravenous administration set with the vent in the open position could result in air embolism. Vented intravenous administration sets with the vent in the open position should not be used with flexible plastic containers. The administration of acetate ions should be done with great care in those conditions in which there is an increased level or an impaired utilization of these ions, such as severe hepatic insufficiency. 

Drug Interactions 

Caution is advised when administering Multiple Electrolytes Injection to patients treated with drugs that may increase the risk of sodium and fluid retention, such as corticosteroids. Caution is advised when administering Multiple Electrolytes Injection to patients treated with drugs which renal elimination is pH dependent. Due to its alkalinizing effect (formation of bicarbonate), Multiple Electrolytes Injection may interfere with the elimination of such drugs. - Renal clearance of acidic drugs such as salicylates and barbiturates may be increased. - Renal clearance of alkaline drugs such as sympathomimetics (e.g., ephedrine, pseudoephedrine), quinidine, or dextroamphetamine (dexamphetamine) sulfate, may be decreased. Renal clearance of lithium may also be increased. Caution is advised when administering Multiple Electrolytes Injection to patients treated with lithium. Because of its potassium content,Multiple Electrolytes Injection, should be administered with caution in patients treated with agents or products that can cause hyperkalemia or increase the risk of hyperkalemia, such as potassium sparing diuretics (amiloride, spironolactone, triamterene), with ACE inhibitors, angiotensin II receptor antagonists, or the immunosuppressants tacrolimus and cyclosporine.

 

Adverse Reactions 

Post-marketing Adverse Reactions The following adverse reactions have been reported with PLASMA-LYTE products without Dextrose. Adverse reactions are listed by MedDRA System Organ Class (SOC), then by Preferred Term in order of severity, where feasible. - Immune System Disorders: Hypersensitivity/infusion reactions, including Anaphylactoid reaction, and the following manifestations: Tachycardia, Palpitations, Chest pain, Chest discomfort, Dyspnea, Respiratory rate increased, Flushing, Hyperemia, Asthenia, Feeling abnormal, Piloerection, Edema peripheral, Pyrexia, - General Disorders and Administration Site Conditions: Infusion site reactions (e.g., Infusion site pain, Burning sensation) Other adverse reactions reported with PLASMA-LYTE products with Dextrose are: - Other manifestations of hypersensitivity/infusion reactions; Hypotension, Wheezing, Urticaria, Cold sweat, Chills – Hyperkalemia.

 

Overdose 

Excessive administration of Multiple Electrolytes Injection may lead to metabolic alkalosis. Metabolic alkalosis may be accompanied by hypokalemia was well as a decrease in ionized serum calcium and magnesium. An excessive volume of Multiple Electrolytes Injection may lead to fluid and sodium overload with a risk of edema (peripheral and/or pulmonary), particularly when renal sodium excretion is impaired. Excessive administration of potassium may lead to the development of hyperkalemia, especially in patients with severe renal impairment. Excessive administration of magnesium may lead to hypermagnesemia. When assessing an overdose, any additives in the solution must also be considered. The effects of an overdose may require immediate medical attention and treatment.


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