Compound Α-keto Acid Tablets

Compound α-keto acid tablets are tablets. The product with the low protein diet, prevention and treatment of chronic renal insufficiency caused by the damage caused by protein metabolism disorders.

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Details

Compound α-keto acid tablets

Introduction

Nombre del Producto: α - ketoacid compuest

Specification: 0.63g

Package: 10tabs in blister; 10blister/box

Standard: CP

Typically used for glomerular filtration rate less than 25 ml per minute in patients. Low protein diet adult daily protein intake of 40 grams or 40 grams.

pharmacology and toxicology

It can be used provide the essential amino acids and to minimize the intake of the amino nitrogen. Ketone or hydroxyl amino acid itself does not contain amino groups, its use of non-essential amino acid nitrogen into amino acids and urea synthesis, thereby reducing the accumulation of uremic toxic products is also reduced. Ketone or hydroxyl amino acid is not caused by ultrafiltration, residual renal units and to improve renal hyperphosphatemia and recurrent hyperparathyroidism of the following method to improve renal osteodystrophy. This product with a low protein diet can reduce the intake of nitrogen, to avoid adverse consequences due to inadequate protein intake and malnutrition. Toxicology studies show opened with the low toxicity. Chronic toxicity studies show that dog poisoning the lowest dose of 1200 mg/day, rats of 2700 mg/day. These dose adjustments for the human body (weight 70 kg) dosage, dogs conversion of 84 g/day, rats conversion of 189 g/day. This product has no embryotoxicity. 


pharmacokinetics

For normal individuals, the oral ketone or hydroxyl amino acids, calcium 10 minutes after the plasma levels will rise, the blood concentration can be increased to 5 times the initial level, and reached its peak after 20 to 60 minutes, 90 minutes and then decreased to normal levels. Plasma ketone or hydroxyl amino acids and the corresponding amino acid concentration increased, the show that ketone or hydroxyl amino acid aminotransferase role soon. Ketone or hydroxyl amino acids in the body has its own way of distribution outside the intake can quickly enter the metabolic cycle, the same catabolic pathways and amino acids.


indications 

with the low protein diet, prevention and treatment of chronic renal insufficiency caused by the damage caused by protein metabolism disorders. Typically used for glomerular filtration rate less than 25 ml per minute in patients. Low protein diet adult daily protein intake of 40 grams or 40 grams. 

usage dosage

oral. Three times a day, a 4 to 8, during dinner, the entire piece to swallow. Prescribed by a doctor when necessary. This dose is 70kg adult weight. Glomerular filtration rate less than 25 ml per minute in patients with the product line with no more than 40 grams a day (adults), low-protein diet may be long-term use. 


adverse reactions

may occur hypercalcemia. Such as hypercalcemia, it is recommended to reduce the amount of vitamin D intake. Continues to occur, the reduction of this product and reduce the intake of other calcium substances, such as hypercalcemia.

[contraindications] hypercalcemia and amino acid metabolism disorder. Hereditary phenylketonuria patients when using this product should be noted that this product contains phenylalanine. 

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