Tegafur,gimeracil and Oteracil Potassium Capsules

Tegafur,gimeracil and Oteracil Potassium Capsules

Gastric cancer, colorectal cancer, head and neck cancers, non-small-cell lung cancer, inoperable or recurrent breast cancer, pancreatic cancer, and biliary tract cancer..

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Details

Tegafur,gimeracil and oteracil potassium capsules


Introduction

Hard capsule,a white or similar white particles or powder inside. 

 

Indications

Product Name (En):Tegafur,Gimeracil and Oteracil Potassium Capsules, TS-1, S-1, Teysuno

Nombre del Producto: Tegafur, gimeracil y oteracilo potasio capsulas

Specification: 20mg

Package: 14caps/blister/box,28caps/blister/box, 42caps/blister/box

Standard: State standard


Ingredients

Tegafur:20mg, Gimeracil:5.8mg, Oteracil potassium:19.6mg;.

 

Use & Dosage

Usually, the standard doses below are defined as the initial dose (single dose) for adults according to body surface area. TS-1 is administered twice daily, after breakfast and after the evening meal, for 28 consecutive days, followed by a 14-day rest. This is regarded as one course of the regimen.


Body surface area (m2)Initial dose (tegafur equivalent)
< 1.2540 mg each time
1.25 - < 1.550 mg each time
≥ 1.560 mg each time


The initial dose can be decreased or increased according to the patient's condition. The doses are staged thus: 40 mg, 50 mg, 60 mg, and 75 mg. If no drug-induced abnormalities in laboratory findings (hematological tests, liver and renal function tests) and no gastrointestinal symptoms occur, i.e., the drug is not problematic in terms of safety, and it is decided to increase the dose, the initial dose can be increased one stage, with an upper limit of 75 mg. It can also be decreased by one stage, and the lower limit is 40 mg.
                        

 

Clinical Pharmacology

Mechanism Of Action

Tegafur is the actual chemotherapeutic agent. It is a prodrug of the active substance fluorouracil (5-FU).

Gimeracil inhibits the degradation of fluorouracil by reversibly blocking a dehydrogenase enzyme. This results in higher 5-FU levels and a prolonged half-life of the substance.

Oteracil mainly stays in the gut because of its low permeability, where it reduces the production of 5-FU by blocking the enzyme orotate phosphoribosyltransferase. Lower 5-FU levels in the gut result in a lower gastrointestinal toxicity


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We are considered as one of the leading manufacturers and suppliers of tegafur,gimeracil and oteracil potassium capsules. With the aid of our technologically advanced manufacturing section, we are able to offer customers tegafur,gimeracil and oteracil potassium capsules products which are tested on various quality parameters in order to supply flawless range at the customers' end.

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