Tegafur,gimeracil and oteracil potassium capsules
Hard capsule,a white or similar white particles or powder inside.
Product Name (En)：Tegafur,Gimeracil and Oteracil Potassium Capsules, TS-1, S-1, Teysuno
Nombre del Producto: Tegafur, gimeracil y oteracilo potasio capsulas
Package: 14caps/blister/box,28caps/blister/box, 42caps/blister/box
Standard: State standard
Tegafur:20mg, Gimeracil:5.8mg, Oteracil potassium:19.6mg;.
Use & Dosage
Usually, the standard doses below are defined as the initial dose (single dose) for adults according to body surface area. TS-1 is administered twice daily, after breakfast and after the evening meal, for 28 consecutive days, followed by a 14-day rest. This is regarded as one course of the regimen.
|Body surface area (m2)||Initial dose (tegafur equivalent)|
|< 1.25||40 mg each time|
|1.25 - < 1.5||50 mg each time|
|≥ 1.5||60 mg each time|
The initial dose can be decreased or increased according to the patient's condition. The doses are staged thus: 40 mg, 50 mg, 60 mg, and 75 mg. If no drug-induced abnormalities in laboratory findings (hematological tests, liver and renal function tests) and no gastrointestinal symptoms occur, i.e., the drug is not problematic in terms of safety, and it is decided to increase the dose, the initial dose can be increased one stage, with an upper limit of 75 mg. It can also be decreased by one stage, and the lower limit is 40 mg.
Mechanism Of Action
Tegafur is the actual chemotherapeutic agent. It is a prodrug of the active substance fluorouracil (5-FU).
Gimeracil inhibits the degradation of fluorouracil by reversibly blocking a dehydrogenase enzyme. This results in higher 5-FU levels and a prolonged half-life of the substance.
Oteracil mainly stays in the gut because of its low permeability, where it reduces the production of 5-FU by blocking the enzyme orotate phosphoribosyltransferase. Lower 5-FU levels in the gut result in a lower gastrointestinal toxicity
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