Irinotecan Injection

Irinotecan Injection

Treating cancer of the colon or rectum. It may be used alone or in combination with other medicines. It may also be used for other conditions as determined by your doctor.

Details

Irinotecan injection

Description

A light yellow transparent liquid.

 

Indications

Product Name:Irinotecan injection, Camptosar

Nombre del Producto: Irinotecán solución inyectable

Specification: 40mg/2ml 100mg/5ml

Package: 1vial/box

Standard: State Standard

Irinotecan is an antineoplastic agent. It works by interfering with the production of proteins necessary for cancer cell growth and reproduction.

 

Side Effect

>10%

Anemia (>90%),Leukopenia (>90%),Neutropenia (>90%),Thrombocytopenia (>90%),Elevated bilirubin (88%),Diarrhea (85%),Nausea (79%),Asthenia (70%),Abdominal pain (63%),Vomiting (60%),Alopecia (43%),Fever (42%),Constipation (41%),Anorexia (34%),Mucositis (32%),Pain (31%),Dyspnea (28%),Cough (27%),Dizziness (23%),Infection (22%),Rash (19%)

1-10%

Abdominal fullness (10%),AST increased (10%),Dyspepsia (10%),,Edema (10%),Ascites/jaundice (9%),Vasodilation (9%),Thromboembolism (9%),Hypotension (6%),Neutropenic fever (2-6%)

Frequency Not Defined

Headache,Insomnia

Orthostatic hypotension

 

Contraindications

Hypersensitivity

Pregnancy

Hereditary fructose intolerance (d/t sorbitol)

 

Precautions

The drug should be administered under the supervision of an experienced cancer chemotherapy physician in facility with appropriate personnel and equipment to diagnose and manage the complications resulting from the therapy.

Early & late forms of severe diarrhea that may be mediated by different mechanisms have been reported. Following the irinotecan infusion, atropine can be used to treat or ameliorate the early diarrhea (occurring shortly after the infusion), which may be accompanied by cholinergic symptoms, including intestinal hyperperistalsis. Late diarrhea (after 24 hr of irinotecan infusion) can be life threatening because it can lead to dehydration, electrolyte imbalance, or sepsis. It should be treated promptly with loperamide, and patients should be given fluid and electrolytes if they become dehydrated or antibiotics if they develop fever.

Severe myelosuppression may occur

 

Pharmacology

Mechanism of Action

Binds to topoisomerase I to produce double-strand breaks in DNA

Pharmacokinetics

Half-Life: 6-12 hr; SN-38 10-20 hr

Pleak Plasma Concentration: 1660 ng/mL; SN-38 26.3 ng/mL

Protein Bound: 30-68%; SN-38 95%

Vd: 110-234 L/m²

Metabolism: hepatic, to SN-38; SN-38 is further metabolized by UGT1A1

Metabolites: SN-38

Clearance: 13-14 L/hr/m²

Excretion: urine, feces


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