Docetaxel Injection

Docetaxel Injection

This medication is used to treat cancer (such as breast, lung, prostate, stomach, and head/neck cancer). Docetaxel is a member of a family of drugs called taxanes. This drug works by slowing cell growth.

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Details

Docetaxel injection

Description

A light yellow to brown transparent liquid. 

Indications

Nombre del Producto: Docetaxel inyectable

Specification: 1ml 20mg ,4ml 80mg

Package: 1vial/box

Standard: USP


Side Effect 

Varies according to indication and treatment regimen

>50%

Alopecia,Anemia,Leukopenia,Neutropenia,Asthenia

10-50%

Fever,Infections,Fluid retention,Hypersensitivity,Skin reactions,Diarrhea,Nausea,Vomiting,Sensory neuropathy,Myalgia,Nail changes

1-10%

Arthralgia,Thrombocytopenia

 

Contraindications

Hypersensitivity to docetaxel or polysorbate 80

Solid tumor with baseline ANC<1500/cu.mm

 

Precautions

Treatment-related mortality higher in patients with hepatic impairment, those receiving higher doses, and in patients with NSCLC and history of prior platinum-based chemotherapy who receive docetaxel as a monotherapy at 100 mg/m²

Monitor for delayed myelodysplasia or myeloid leukemia in patients who received docetaxel injection concentrate, doxorubicin and cyclophosphamide

Coadministration with CYP3A4 inhibitors may increase exposure to docetaxel and should be avoided; consider docetaxel dose reduction if unable to avoid

Consider adjusting dose if cutaneous reactions like erythema of the extremities with edema followed by desquamation occur

 

Pharmacology

Mechanism of Action

Semisynthetic taxane, prevents depolymerization of cellular microtubules, which results in DNA, RNA, and protein synthesis inhibition

Pharmacokinetics

Half-life elimination: 11 hr (terminal)

Protein bound: 94-97%

Vd: 80-90 L/m²

Metabolism: Liver (CYP3A4)

Clearance: 21 L/hr/m²

rExcretion: Feces 75%; urine 6%


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