Somatropin (RDNA Origin) Injection

Somatropin (RDNA Origin) Injection

It is a prescription product for the replacement of growth hormone in adults with growth hormone deficiency (GHD) that started either in childhood or as an adult.

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Details

Somatropin (rDNA origin) injection

Introduction

Product Name:Somatropin (rDNA origin) injection, Jintropin,Genotropin, Humatrope, Norditropin, Nutropin, Serostim, Zorbtive

Nombre del Producto: Somatropina (origen rDNA) inyección

Specification: 15iu/5mg, 30iu/10mg, 3ml catridge

Package: 3ml catridge

Standard: BP

Indications

Pediatric growth hormone deficiency

Severe burns

Adult Growth hormone deficiency

Dosage and administration

* The dose of administration should be individual for each patient. For growth-promotion purpose in children, the recommended dose is 0.1-0.15 IU/kg/day, once per day, subcutaneous injection. The period of treatment is from 3 months to 3 years. Or follow your physicians prescription.

*For severe burn patients, a daily dose of 0.2-0.4I U/kg subcutaneous injection is recommended. The period of treatment is about 2 weeks.

*The dose might require adjustment individually for human GH replacement therapy. Pls follow your  physicians instructions.

 

Side effects 

Common adverse reactions reported in adult and pediatric patients taking somatropin include injection site reactions. Additional common adverse reactions in adults include edema, arthralgia, and carpal tunnel syndrome.


CONTRAINDICATIONS

Acute critical illness

Prader-Willi syndrome (PWS) in children

Active malignancy

Diabetic retinopathy

Closed epiphyses

Hypersensitivity

Interactions

Somatropin inhibits 11ß-hydroxysteroid dehydrogenase type 1 (11ßHSD-1) in adipose/hepatic tissue and may significantly impact the metabolism of cortisol and cortisone. As a consequence, in patients treated with somatropin, previously undiagnosed central (secondary) hypoadrenalism may be unmasked, requiring glucocorticoid replacement therapy

Careful monitoring is advisable when somatropin is administered in combination with insulin and/or other hypoglycemic agents, other drugs metabolized by CYP450 liver enzymes (eg, hydrocortisone or other corticosteroids, sex steroids, anticonvulsants, cyclosporine), or other hormone replacement therapy

 

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