Product name: Piperacillin sodium for injection
Specification: 0.5g, 1g, 4g
Shelf Life: 3 Years
Piperacillin sodium for injection
The main ingredients and chemical name of this product are:
Piperacillin sodium; (2S,5R,6R)-3.3-dimethyl-6-[(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)phenylacetamido]-7 Oxo-4-thiaze-1- azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt.
Molecular formula: C23H26N5NaO7S
Molecular weight: 539.54
This product is white or almost white powder or loose block; odorless; easily wet.
It is suitable for sepsis caused by sensitive Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter, upper urinary tract and complicated urinary tract infections, respiratory infections, biliary tract infections, abdominal infections, pelvic infections, and skin and soft tissue infections. The combination of piperacillin and aminoglycosides can also be used in patients with neutropenia immunodeficiency.
Calculations for C23H27N5O7S (1) 0.5g; (2) 1.0g; (3) 4.0g.
This product can be intravenously and intravenously.
Adult moderate infection 8g a day, divided into 2 intravenous drip; serious infection once 3 ~ 4g, intravenous infusion or injection every 4 to 6 hours. The total daily dose does not exceed 24g.
The dosage for infants and children under 12 years of age is 100-200 mg/kg body weight per day. Newborns weighing less than 2 kg, 50 mg/kg every 12 hours during the first week after birth, intravenous drip; 50 mg/kg from the second week, once every 8 hours. Newborns weighing more than 2kg were given 50mg/kg every 8 hours for the first week after birth, and 50mg/kg for every 6 hours for more than 1 week.
1. Allergic reaction: allergic reactions to penicillin drugs are more common, including rashes and other rashes, leukopenia, interstitial nephritis, asthma attacks, and serum sickness reactions. Severe cases such as anaphylactic shock may occur. Once anaphylactic shock occurs, Must be rescued on the spot, to maintain the airway smooth, oxygen and give epinephrine, glucocorticoids and other treatment measures.
2. Local symptoms: local injection site pain, thrombophlebitis, etc.
3. Gastrointestinal symptoms: diarrhea, loose stools, nausea, vomiting, etc.;
pseudomembranous colitis rare.
4. Cholestatic jaundice can occur in individual patients.
5. Central nervous system symptoms: headache, dizziness, and tiredness.
6. When a large dose of renal insufficiency is applied, penicillin encephalopathy occurs due to an increase in the concentration of cerebrospinal fluid, so dose adjustment should be performed according to renal function.
7. Others: Candida secondary infection, bleeding, etc.
Patients with a history of penicillin allergy or penicillin skin test were banned.
1. Before using this product, you need to ask in detail about the history of drug allergy and penicillin skin test. Positive responders are forbidden.
2. People allergic to penicillin may be allergic to other penicillins; those who are allergic to cephalosporins, cephamycins, griseofulvin or penicillamine may also be allergic to this product.
3. This product can cause bleeding in a small number of patients, especially patients with renal insufficiency, should be promptly discontinued after the occurrence and appropriate treatment; renal dysfunction should be appropriately reduced.
4. Interference with Diagnosis: The use of this product can cause a positive Coomabs test, as well as elevated blood urea nitrogen and serum creatinine, hypernatremia, hypokalemia, serum aminotransferase, and serum lactate. Increased dehydrogenase and increased serum bilirubin.
5. Allergies, bleeding history, ulcerative colitis, Crohn's disease, or antibiotic-associated enteritis should be used with caution.
6. This product can not be added in sodium bicarbonate solution infusion.
Sealed and kept in a dry place.