Product name: Cloxacillin sodium for injection
Specification: 0.25g, 0.5g, 1g
Shelf Life: 3 Years
Cloxacillin sodium for injection
The main ingredient of this product is cloxacillin sodium.
The chemical name is (2S,5R,6R)-3,3-dimethyl-6-[5-methyl-3-(2-chlorophenyl)-4-isoxazolecarboxamido]-7-oxo 4-Bromo-1-azabicyclo[3.2.0]heptane-2-carboxylate sodium salt.
Molecular Formula: C19H17ClN3NaO5S
Molecular weight: 457.87
This product is white powder or crystalline powder.
This product is only suitable for the treatment of penicillinase producing staphylococci infection, including sepsis, endocarditis, pneumonia and skin, soft tissue infections. It can also be used for mixed infections caused by Streptococcus pyogenes or pneumococcus and penicillin resistant staphylococci.
0.25g,0.5g,1g (calculated as C19H18ClN3O5S)
1, intramuscular injection of adult daily 2g, divided into 4 times, children daily by body weight 25 ~ 50mg/kg, divided into 4 times. Intramuscular injection can add 0.5% lidocaine to reduce local pain.
2, intravenous infusion of adults on the 1st 4 ~ 6g, divided 2 ~ 4 times; children on the 1st according to body weight 50 ~ 100mg/kg, points 2 ~ 4 times.
3, newborns weighing less than 2kg, day 1 to 14 days when every 12 hours according to body weight to 25mg/kg, day 15 to 30 days when every 8 hours according to body weight to 25mg/kg; body weight over 2kg, age 1 On the 14th day, the body weight was 25 mg/kg every 8 hours, and the body weight was 25 mg/kg every 6 hours for 15 to 30 days.
Patients with mild to moderate renal impairment do not need to adjust the dose. Patients with severe renal impairment should avoid the use of large doses in order to prevent the occurrence of toxic reactions in the central nervous system.
1, allergic reactions: urticaria and other types of skin rash is more common,
leukopenia, interstitial nephritis, asthma attacks and serum sickness may also occur, severe cases such as anaphylactic shock may occur; anaphylactic shock occurs once , must be on the spot to rescue, keep the airway open, oxygen and adrenaline, glucocorticoids and other treatment measures.
2, intravenous injection of this product can produce nausea, vomiting and elevated serum aminotransferase.
3, large doses of this product can cause convulsions and other central nervous system toxicity.
4. Hematuria, proteinuria, and uremia have been reported in infants after large doses of this product.
5, individual cases of agranulocytosis or cholestatic jaundice. Occasionally double infection.
Patients with history of penicillin allergy or positive penicillin skin test were banned.
1, before the application of this product need to ask about the history of drug allergy and penicillin skin test.
2. Patients with a penicillin allergy may be allergic to other penicillins or penicillamines.
3, patients with asthma, eczema, hay fever, urticaria and other allergic diseases should be used with caution.
4, this product reduces the ability of patients with bilirubin and serum protein binding, especially for newborns who have jaundice with this product.
Sealed and kept in a dry place.