Cefuroxime For Injection

Product name: Cefuroxime for injection
Package: 10vials/box, 300vials/carton
Specification: 0.75g, 1.5g


Product name: Cefuroxime for injection

Package: 10vials/box, 300vials/carton

Specification: 0.75g, 1.5g



OEM: Available

Shelf Life: 3 Years

Cefuroxime for injection

Cefuroxime for injection

Cefuroxime for injection 0.75g 1.5g

Cefuroxime for injection 0.75g 1.5g

Product Details


This product is mainly composed of cefuroxime sodium.

Chemical name: (6R ,7R)-7-[2-furyl(methoxyimino)acetylamino]3-carbamoyloxymethyl-8-oxo-5-thia-1-azabicyclo [4.2.0] Oct-2-en-2-methyl sodium salt.

Chemical Structure:


Molecular formula: C16H15N4NaO8S

Molecular weight: 446.37


This product is white to light yellow powder or crystalline powder.


This product can be used for the following infections caused by cefuroxime sensitive bacteria:

1. Respiratory tract infection: Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin-resistant bacteria), Klebsiella spp., Staphylococcus aureus (producing strains of penicillinase-producing bacteria and non-penicillinase-producing bacteria), and pus Respiratory infections caused by Streptococcus and E. coli, such as acute and chronic bronchitis, bronchiectasis, bacterial pneumonia, lung abscess, and postoperative lung infections.

2, ENT infections: otitis media, sinusitis, tonsillitis, pharyngitis.

3, urinary tract infections: E. coli and Klebsiella bacteria caused by urinary tract infections, such as acute and chronic pyelonephritis, cystitis and asymptomatic bacteriuria.

4. Skin and soft tissue infections: caused by Staphylococcus aureus (producing strains of penicillinase-producing and non-penicillinase-producing bacteria), Streptococcus pyogenes, Escherichia coli, Klebsiella, and Enterobacter bacteria Skin and soft tissue infections such as cellulitis, erysipelas, peritonitis, and wound infections.

5. Septicemia: Staphylococcus aureus (producing strains of ampicillin and non-penicillinase-producing bacteria), Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae (including ampicillin resistant strains) and Klebsiella species Septicemia caused by bacteria.

6. Meningitis: caused by Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin-resistant bacteria), Neisseria meningitidis, and Staphylococcus aureus (producing enzymes of penicillinase and non-penicillinase-producing bacteria) Meningitis.

7, gonorrhea: Neisseria gonorrhoeae (penicillin enzyme-producing bacteria and non-penicillin enzyme-producing bacteria) caused by simple (without complications) and complications of gonorrhea, especially for those who are not suitable for penicillin treatment.

8. Bone and Joint Infections: Bone and joint infections caused by Staphylococcus aureus (protease produced by penicillinase and non-penicillinase-producing bacteria).

This product can still be used to prevent the growth of sensitive pathogens before surgery or surgery, and reduce the infection caused by contamination during and after surgery. Such as abdominal pelvic and orthopedic surgery, heart, lungs, esophagus and vascular surgery, total joint replacement surgery to prevent infection.


This product can be injected deep muscles, but also intravenous injection or infusion.

For intramuscular administration, the product is dissolved in 1.0 ml of sterile water for injection or 0.75 g in 3 ml of sterile water for injection, and the product is slowly shaken to obtain a suspension for deep muscle injection. Before intramuscular injection, blood must be drawn back before injection.

Intravenous injection: 0.25g is dissolved with at least 2.0ml of sterile water for injection, 0.75g is dissolved with at least 6.0ml of sterile water for injection, 1.5g is dissolved with at least 15ml of sterile water for injection, shaken and then intravenously injected slowly, and intravenous can also be added. Infusion tube infusion.

Intravenous infusion: 1.5g of cefuroxime can be added to at least 50ml of commonly used intravenous injections, and can not be used in combination with aminoglycoside antibiotics.

This product is commonly used in adults for each 0.75g, every 8 hours of administration, treatment for 5-10 days, for life-threatening serious infections or infection caused by rare strains, can be increased to 1.5g each time, daily 3 Times; if necessary, the interval can be increased to once every 6 hours, the total daily amount of 3-6g. For bacterial meningitis, the dose should not exceed 3.0 g every 8 hours. For simple gonorrhea, a single dose of 1.5g should be injected intramuscularly on both hips.

Prevention of surgical infections: 1.5-1.5 hours before surgery intravenously 1.5g of this product, if the operation is too long, then every 8 hours intravenously or intramuscular injection of 0.75g dose. In the case of thoracic surgery, intravenous injection of 1.5 g should be performed with the introduction of anesthetic; once every 12 hours, the total dose should be 6 g.

For children more than 3 months old, 50-100 mg per kilogram of body weight will be given in 3-4 doses. For severe infections, use no less than 0.1 g/kg of body weight per day but not exceed the maximum dose used by adults. Bone and joint infections, 0.15g per kilogram body weight per day (not to exceed the maximum dose used by adults), divided into three doses. Meningitis patients daily 0.2-0.24g per kilogram of body weight, 3-4 doses.

In patients with renal insufficiency, the usage and dosage should be adjusted according to the degree of renal impairment. The recommended adjustment method is shown in the following table.

Children with renal insufficiency should also be adjusted with reference to the following table.

Creatinine clearance (ml/min) Dose Interval

>20 0.75-1.5g every 8h

10-20 0.75g every 12h

<10 0.75g per 24h

For patients undergoing dialysis, a single dose of 0.75g should be given at the end of dialysis.

Adverse reactions

This product is well tolerated and common adverse reactions are as follows:

1, local reactions: such as muscle injection site pain, thrombophlebitis.

2, gastrointestinal reactions: such as diarrhea, nausea, pseudomembranous colitis and so on.

3, allergic reactions: common rash, itching, urticaria and so on. Occasional allergy, drug fever, erythema multiforme, interstitial nephritis, toxic exfoliative dermatitis, and Stevens Johnson syndrome.

4, blood: visible hemoglobin and hematocrit reduction, transient eosinophilia, transient neutropenia and leukopenia, and occasionally thrombocytopenia.

5, liver function: visible ALT, AST, alkaline phosphatase, lactate dehydrogenase and serum bilirubin transient increase.

6, other: still see vomiting, abdominal pain, conjunctivitis, vaginitis (including vaginal candidiasis), abnormal liver function (including cholestasis), aplastic anemia, hemolytic anemia, bleeding, triggering epilepsy, prothrombin time Prolonged, various types of cytopenia, agranulocytosis and so on.


This product is banned for cephalosporins or cephamycin drug allergies.


1, this product and penicillin cross-allergic reaction. For those who are allergic to penicillin drugs, use this product with caution. Penicillin anaphylactic shock, should not choose this product.

2, when using this product, should pay attention to monitor renal function, especially for patients receiving high-dose severe illness.

3, renal insufficiency should reduce the daily dose. Patients who are treated with a combination of potent diuretics or aminoglycoside antibiotics should pay special attention because there have been reports of renal impairment caused by combination therapy. For these patients, renal function monitoring is best.

4, this product can cause pseudomembranous colitis, patients with a history of gastrointestinal disease, especially ulcerative colitis, localized colitis or antibiotic-associated colitis, should be vigilant.

After the diagnosis of pseudomembranous colitis is established, appropriate treatment should be given. Mild patients can be stopped, moderate and severe should be given liquids, electrolytes, protein supplements, and need to use antibiotics for Clostridium effective antibiotics.

5. It has been reported that minor children have mild to moderate hearing impairments when using this product.

6, compatibility and stability:

Intramuscular injection: When formulated with sterile water for injection, the suspension of the product can be kept at room temperature for 24 hours and refrigerator at 5°C for 48 hours to maintain the activity. After this period, any unused solution should be discarded.

Intravenous injection: When formulated with sterile water for injection, 750 mg, 1.5 g of the prepared solution is allowed to stand at room temperature for 24 hours, and the refrigerator is stored at 5° C. for 48 hours to maintain the activity.

This product can maintain compatibility with the following solutions at room temperature within 24 hours: heparin (10-50u/ml), potassium chloride (10-40mEq/l), 0.9% sodium chloride. This product is 750mg and 1.5g, with 50ml or 100ml 5% glucose injection, 0.9% sodium chloride injection, 0.45% sodium chloride injection diluted, can be stored at room temperature for 24 hours, refrigerator storage for 7 days.

7. Interference to diagnosis: This product can interfere with the direct Coombs test results, there is a positive reaction, this phenomenon will interfere with the blood cross-fitting; will appear when the urine sugar is tested on the Benedict test or the Felling's test or Clintest tabets test paper A false positive reaction, but no false positives when tested by the enzyme method. In the case of blood sugar, false negative results may occur with the method of ferricyanide, and cefuroxime sodium does not interfere with the determination of urine and blood inosine by the alkaline picric acid method.


Shading, sealed, kept in a cool (no more than 20°C) dry place

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