Cefazolin for Injection

Cefazolin for Injection

Cefazolin sodium, is a semi synthetic cephalosporin with a potent bactericidal action against most gram-positive and a large spectrum of gram-negative organisms. It provides high and prolonged blood levels after injection and is excreted unchanged in the urine.

Details

Cefazolin for injection

Instruction

Product Name:Cefazolin sodium for Injection

Nombre del Producto:Cefazolina sódica para solución inyectable

Specification: 500mg,1g

Package: 10viales/box, 50viales/box, 100viales/box

Standard: BP & USP & CP


Indications

It is indicated in the treatment of: 

-Respiratory tract infections, acute and subacute bronchitis, bronchopneumonia, pneumo-pulmonary abscess, pharyngitis, laryngitis and tonsiiitis. 

- Septicemia and subacute bacterial endocarditis. 

- Cholangitis, cholecystitis, peritonitis, lymphangitis and lymphadenitis. 

- Genitourinary tract infections. 

-Osteomyelitis, arthiritis, folliculitis, furunculosis, atheroma, carbuncle, erysipelas, abscess, post-operative wound infections, wound infections, burns and scalds.

 

Dosage and administration

Cefazolin for Injection, USP may be administered either intramuscularly or intravenously

after constitution. In both cases, total daily dosages are the same.

Treatment should be continued in beta-hemolytic streptococcal infections for at least

10 days to minimize possible complications associated with the disease.

After reconstitution 

1 - Mild-moderate Infections: 

- Adults: 500 mg - 1 gm every 12 hours. 

- Children: 25 - 50 mg/kg/day in 3 or 4 equally divided doses. 

2 - Moderate - severe infections: 

- Adults: 500 mg -1 gm every 6 - 8 hours. 

- Children: up to 100 mg/kg/day in 3 or 4 equally divided doses.

 

Contra-indications

Sterile cefazolin sodium is contraindicated in patients with known allergy to the cephalosporin

group of antibiotics.

 

Warnings

Sterile cefazolin sodium should be used with caution in penicillin-allergic patients. There is

clinical evidence of partial cross-allergenicity of the penicillins and the cephalosporins. There

are instances of patients who have had reactions to both penicillins and cephalosporins (including

fatal anaphylaxis after parenteral use). Clinical and laboratory evidence of partial crossallergenicity

of the two drug classes exists.

Sterile cefazolin sodium should be administered cautiously and then only when absolutely

necessary to any patient who has demonstrated allergy, particularly to drugs. Immediate

emergency treatment with epinephrine is indicated for serious anaphylactoid reactions. As

indicated, oxygen, intravenous steroids, and airway management including intubation, should

also be employed.

There have been reports of pseudo membranous colitis with the use of cephalosporins. It is

therefore important to consider its diagnosis in patients who develop diarrhea in association with

antibiotic use.

 

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