Amoxicillin for Injection

Amoxicillin sodium for injection is also indicated for the treatment and prophylaxis of endocarditis. Consideration should be given to official guidance on the appropriate use of antibacterial agents.

Details

Amoxicillin for injection

Indications

Amoxicilline sodium for injectionis indicated for the treatment of the following infections in adults and children

• Severe infections of the ear, nose and throat (such as mastoiditis, peritonsillar infections, epiglottitis, and sinusitis when accompanied by severe systemic signs and symptoms)

• Acute exacerbations of chronic bronchitis

• Community acquired pneumonia

• Acute cystitis

• Acute pyelonephritis

• Severe dental abscess with spreading cellulitis

• Prosthetic joint infections

• Lyme disease

• Bacterial meningitis

• Bacteremia that occurs in association with, or is suspected to be associated with, any of the infections listed above

Product Name:Amoxicillin sodium for injection

Nombre del Producto: Amoxicilina sódico para solución inyectable

Specification: 500mg,1g

Package: 10viales/box, 50viales/box, 100viales/box

Standard: BP& CP


Usage and Dosage 

Treatment of Infections in Adults and the Elderly

By intramuscular injection: 500mg every eight hours.

By intravenous injection or infusion: 500mg every eight hours (or in severe infection 1g every six hours) may be given by slow iv injection over three to four minutes or by infusion over 30 to 60 minutes.

Treatment of Infection in Children up to 10 years

By intramuscular or intravenous injection or infusion: 50-100mg per kg bodyweight daily in divided doses.

 

Contraindications

Amoxicillin should not be given to patients with a history of hypersensitivity to the beta-lactam antibiotics (e.g. penicillins, cephalosporins).

Bacterial resistance to amoxicillin or ampicillin.

 

Special warnings and precautions for use

Serious and occasionally fatal hypersensitivity (anaphylactoid) reactions have been reported in patients on penicillin therapy. These reactions are more likely to occur in individuals with a history of hypersensitivity to beta-lactam antibiotics.

If a hypersensitivity reaction is reported, treatment with amoxicillin must be discontinued.

Discontinue treatment if skin rash appears.

Amoxicillin-induced flare of DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) has been reported.

 

Interaction with other medicinal products and other forms of interaction

Broad spectrum antibiotics including amoxicillin may increase the effects of oral anticoagulants or they may reduce the effects of oral anticoagulants. In the literature there are rare cases of increased INR in patients maintained on acenocoumarol or warfarin and prescribed a course of amoxicillin. If co-administration is necessary, the prothrombin time or INR should be carefully monitored with the addition or withdrawal of amoxicillin.

In common with other antibiotics, amoxicillin may affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral contraceptives.

Probenecid decreases the renal tubular secretion of amoxicillin. Concurrent use with amoxicillin may result in increased and prolonged blood levels of amoxicillin.

There is reduced excretion of methotrexate (increased risk of toxicity).

There may be antagonism between amoxicillin and bacteriostatic agents such as chloramphenicol. An increased frequency of skin rashes has been reported in patients receiving amoxicillin together with allopurinol, compared to those receiving amoxicillin alone.

Tetracyclines may reduce the effectiveness of penicillins particularly in the treatment of infections such as pneumococcal meningitis and scarlet fever.

Penicillins may produce false-positive results with the direct antiglobulin (Coombs') test.

Penicillins may produce falsely high urinary glucose results with the copper sulphate test.

Glucose enzymatic tests such as the glucose oxidase test are not affected by penicillins.

Penicillins may produce falsely high urinary protein results.

Bromophenol blue reagent test strips are not affected by penicillins.

 

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